Baker Mayfield’s 4-1 start has him among the NFL MVP chatter as Tampa Bay rides late-season magic to a potential NFC title tilt. A Week 6 date with San Francisco tests the Buccaneers’ mettle and Mayfield’s clock-management against a stingy defense.

Ahead, fantasy eyes focus on Week 6 breakout bets, from Mayfield’s efficiency in key quarters to the slate’s top playmakers, run games, and red-zone dynamics. The picks section stacks implications for QBs, receivers, and backfields in a high-variance, high-reward environment.

Las Vegas sits at 1-4 as Pete Carroll navigates a rebuild under the Raiders’ spotlight, with Ashton Jeanty adding spark and Geno Smith referenced as the QB he inherited. Maxx Crosby anchors a defense that must carry more weight while the offense seeks cohesion. Carroll’s mindset mirrors his USC grit: process, trust, and a belief the install will click. With Titans and Chiefs on deck, fantasy managers should monitor role clarity, pace of the system, and potential breakout through the rest of the schedule.

Indy dominated the Raiders 40-6 behind a balanced attack and a relentless defense. Daniel Jones looked like the franchise quarterback Indy hoped for, delivering 212 yards and two touchdowns with composure under pressure. Jonathan Taylor punched in three scores as Indy carved out a red-zone clinic (6-for-6). Defensively, four Colts sack a list of stalwarts while Laiatu Latu and Mehki Blackmon delivered timely takeaways. Special teams shone with a blocked punt by Segun Olubi as Indy proved it can win in all three phases.

Offensive cohesion and red-zone efficiency were the storylines, but the Colts’ improved protection allowed Jones to exploit Raiders’ coverage and keep the momentum. With several pass-catchers contributing, Indy’s weapons pool looks more versatile than earlier in the season, giving fantasy managers a clearer path to steady weekly points and upside in a favorable schedule ahead.

Las Vegas dropped to 1-4 after a 40-6 meltdown at Indianapolis, spotlighting widespread issues on offense, defense, and special teams. Pete Carroll’s postgame remarks balanced accountability with a push for growth from the young players and a plan to clean up the mistakes. The defeat raises urgency as the Raiders prepare for a home matchup amid leadership questions and rotation tweaks.

Colts dominated clock time on third downs, a blocked punt swung momentum, and a late interception iced the game. With Brock Bowers and Eric Stokes rested, the vibe centers on leadership, rotation decisions, and how the Raiders recalibrate for a bounce-back effort in Week 6.